Question 1

Which of the following hormones is able to cross biological membranes and thus the receptor is found inside the cell, not on the cell surface?

Accepted Answer

A)   insulin
B)   glucagon
C)   cortisol
D)   epinephrine
E)   platelet derived growth factorF) D) and E)
G) A) and C)

Question 2

Which of the following is a ligand of the   β\betaβ  2-adrenergic receptor?

Accepted Answer

A)   tyrosine
B)   serotonin
C)   norepinephrine
D)   caffeine
E)   adenosine F) All of the above
G) A) and B)

Question 3

Which of the following can be regulated by eicosanoids?

Accepted Answer

A)   blood pressure
B)   blood coagulation
C)   inflammation
D)   fever
E)   all of the aboveF) C) and D)
G) B) and C)

Question 4

The eicosanoids are derived from the membrane fatty acid _____.

Accepted Answer

A)   stearic acid
B)   linoleic acid
C)     α\alphaα  -linolenic acid
D)   arachidonic acid
E)   docosahexaenoic acid (DH
A)   F) All of the above
G) B) and C) D

Question 5

In order for cAMP to ___ protein kinase A, cAMP binds to the ___ subunits.

Accepted Answer

activate, ...

Question 6

The ability for some receptor tyrosine kinases to ultimately activate phospholipase C is an example of _____.

Accepted Answer

A)   antagonism
B)   desensitization
C)   autophosphorylation
D)   poor receptor-ligand specificity
E)   cross-talkF) B) and D)
G) A) and E) E

Question 7

Activity of the Ras protein is analogous to the _____ in terms of its ability to bind GTP.

Accepted Answer

A)   G protein   α\alphaα   subunit
B)   G protein   β\betaβ   subunit
C)   G protein   γ\gammaγ   subunit
D)   calmodulin
E)   all of the above F) None of the above
G) A) and D)

Question 8

The action of a ___ results in the hydrolysis of cAMP, thus decreasing the signal from ___.

Accepted Answer

phosphodie...

Question 9

Interaction of the Ras protein with ___ results in activation by ___

Accepted Answer

an adaptor...

Question 10

The complex formed between a lipid hormone and its receptor binds to _____ which are specific DNA sequences.

Accepted Answer

A)   transcription factors
B)   nuclear localization sequences
C)   DNA-binding domains
D)   hormone response elements
E)   none of the aboveF) C) and E)
G) B) and E)

Question 11

Which of the following is an inhibitor of cyclooxygenase?

Accepted Answer

A)   acetaminophen
B)   aspirin
C)   eicosanoic acid
D)   thromboxane
E)   progesteroneF) None of the above
G) B) and D)

Question 12

Which of the following can be a hormone?

Accepted Answer

A)   amino acid derivatives
B)   steroids
C)   polypeptides
D)   eicosanoids
E)   all of the aboveF) All of the above
G) A) and C)

Question 13

When a receptor loses its ability to transmit a signal following continuous exposure to a ligand, the receptor is said to be _____.

Accepted Answer

A)   saturated
B)   desensitized
C)   transduced
D)   specific
E)   none of the aboveF) A) and E)
G) B) and C)

Question 14

The _____ signaling pathway undergoes autophosphorylation, resulting in kinase activation.

Accepted Answer

receptor t...

Question 15

Hormones bind to _____ with _____ affinity.

Accepted Answer

A)   ligands; low
B)   agonists; high
C)   antagonists; low
D)   G proteins; low
E)   receptors; highF) A) and B)
G) A) and C)

Question 16

A sample of cells with a total receptor concentration of 50   μ\muμ  M was incubated with a ligand concentration of 100   μ\muμ  M. Following the incubation period, the concentration of unbound receptors was determined to be 15   μ\muμ  M. What is the Kd for the receptor-ligand interaction?

Accepted Answer

A)   28   μ\muμ  M
B)   43   μ\muμ  M
C)   143   μ\muμ  M
D)   217   μ\muμ  M
E)   333   μ\muμ  M F) C) and E)
G) B) and E) A

Exam 10: Signaling

Which of the following hormones is able to cross biological membranes and thus the receptor is found inside the cell, not on the cell surface?

Correct Answer
verified

Which of the following is a ligand of the $\beta$ ₂-adrenergic receptor?

Correct Answer
verified

Which of the following can be regulated by eicosanoids?

Correct Answer
verified

The eicosanoids are derived from the membrane fatty acid _____.

Correct Answer
verified
D

In order for cAMP to _ protein kinase A, cAMP binds to the _ subunits.

Correct Answer
verified
activate, ...
View Answer

The ability for some receptor tyrosine kinases to ultimately activate phospholipase C is an example of _____.

Correct Answer
verified
E

Activity of the Ras protein is analogous to the _____ in terms of its ability to bind GTP.

Correct Answer
verified

The action of a _ results in the hydrolysis of cAMP, thus decreasing the signal from _.

Correct Answer
verified
phosphodie...
View Answer

Interaction of the Ras protein with _ results in activation by _

Correct Answer
verified
an adaptor...
View Answer

The complex formed between a lipid hormone and its receptor binds to _____ which are specific DNA sequences.

Correct Answer
verified

Which of the following is an inhibitor of cyclooxygenase?

Correct Answer
verified

Which of the following can be a hormone?

Correct Answer
verified

When a receptor loses its ability to transmit a signal following continuous exposure to a ligand, the receptor is said to be _____.

Correct Answer
verified

The _____ signaling pathway undergoes autophosphorylation, resulting in kinase activation.

Correct Answer
verified
receptor t...
View Answer

Hormones bind to _ with _ affinity.

Correct Answer
verified

A sample of cells with a total receptor concentration of 50 $\mu$ M was incubated with a ligand concentration of 100 $\mu$ M. Following the incubation period, the concentration of unbound receptors was determined to be 15 $\mu$ M. What is the K_d for the receptor-ligand interaction?

Correct Answer
verified
A

Exam 10: Signaling

Which of the following hormones is able to cross biological membranes and thus the receptor is found inside the cell, not on the cell surface?

Correct AnswerverifiedShow Answer

Which of the following is a ligand of the β\betaβ 2-adrenergic receptor?

Correct AnswerverifiedShow Answer

Which of the following can be regulated by eicosanoids?

Correct AnswerverifiedShow Answer

The eicosanoids are derived from the membrane fatty acid _____.

Correct AnswerverifiedD

In order for cAMP to ___ protein kinase A, cAMP binds to the ___ subunits.

Correct Answerverifiedactivate, ...View AnswerShow Answer

The ability for some receptor tyrosine kinases to ultimately activate phospholipase C is an example of _____.

Correct AnswerverifiedE

Activity of the Ras protein is analogous to the _____ in terms of its ability to bind GTP.

Correct AnswerverifiedShow Answer

The action of a ___ results in the hydrolysis of cAMP, thus decreasing the signal from ___.

Correct Answerverifiedphosphodie...View AnswerShow Answer

Interaction of the Ras protein with ___ results in activation by ___

Correct Answerverifiedan adaptor...View AnswerShow Answer

The complex formed between a lipid hormone and its receptor binds to _____ which are specific DNA sequences.

Correct AnswerverifiedShow Answer

Which of the following is an inhibitor of cyclooxygenase?

Correct AnswerverifiedShow Answer

Which of the following can be a hormone?

Correct AnswerverifiedShow Answer

When a receptor loses its ability to transmit a signal following continuous exposure to a ligand, the receptor is said to be _____.

Correct AnswerverifiedShow Answer

The _____ signaling pathway undergoes autophosphorylation, resulting in kinase activation.

Correct Answerverifiedreceptor t...View AnswerShow Answer

Hormones bind to _____ with _____ affinity.

Correct AnswerverifiedShow Answer

A sample of cells with a total receptor concentration of 50 μ\muμ M was incubated with a ligand concentration of 100 μ\muμ M. Following the incubation period, the concentration of unbound receptors was determined to be 15 μ\muμ M. What is the Kd for the receptor-ligand interaction?

Correct AnswerverifiedA

Correct Answer
verified

Which of the following is a ligand of the $\beta$ ₂-adrenergic receptor?

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
D

In order for cAMP to _ protein kinase A, cAMP binds to the _ subunits.

Correct Answer
verified
activate, ...
View Answer

Correct Answer
verified
E

Correct Answer
verified

The action of a _ results in the hydrolysis of cAMP, thus decreasing the signal from _.

Correct Answer
verified
phosphodie...
View Answer

Interaction of the Ras protein with _ results in activation by _

Correct Answer
verified
an adaptor...
View Answer

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
receptor t...
View Answer

Hormones bind to _ with _ affinity.

Correct Answer
verified

A sample of cells with a total receptor concentration of 50 $\mu$ M was incubated with a ligand concentration of 100 $\mu$ M. Following the incubation period, the concentration of unbound receptors was determined to be 15 $\mu$ M. What is the K_d for the receptor-ligand interaction?

Correct Answer
verified
A