Question 1

Eukaryotic genes consist of protein-coding sequences and adjacent regulatory sequences.

Accepted Answer

A) True 
 B)False

Question 2

What happens to a DNA promoter sequence when it is methylated?

Accepted Answer

A)  It is temporarily silenced because the methyl group can be removed.
B)  It is temporarily transcribed because the methyl group can be removed.
C)  It is perpetually transcribed because the methyl group can never be removed.
D)  It is permanently silenced because the methyl group can never be removed.E) B) and C)
F) C) and D)

Question 3

Match each term with its definition.
-operon

Accepted Answer

A)  regulatory protein that activates the expression of an operon's genes
B)  interfering RNA molecules originally encoded by nuclear DNA
C)  process of controlling the expression of genes that takes place at the DNA level
D)  regulatory protein that prevents an operon's genes from being expressed
E)  inhibition of transcription via DNA methylationF) interfering RNA molecules associated with some viral life cyclesG) tumour comprising cells that invade and disrupt the surrounding tissuesH) increases expression of an operon's genesI) cluster of prokaryotic genes and their associated DNA regulatory sequencesJ) tumour comprising undifferentiated cells that stay together in a single massK) spread of malignant cells through the blood or lymphatic systemL) removes a nucleosome from DNA to expose a promoterM) F) and L)
N) C) and I)

Question 4

What is one function of the 5? UTR (untranslated region)  of mRNA?

Accepted Answer

A)  to decrease the half-life of mRNA
B)  to extend the half-life of mRNA
C)  to stabilize the mRNA structure
D)  to control the half-life of mRNAE) A) and B)
F) A) and D)

Question 5

Genes in operons are transcribed in such a way as to share which of the following molecules?

Accepted Answer

A)  mRNA
B)  tRNA
C)  protein
D)  ribosomeE) None of the above
F) B) and C)

Question 6

Suppose that you observe a mutant E. coli in which CAP is always inactive. In the presence of lactose and low levels of glucose, what would you expect the gene expression from this mutant's lac operon to be?

Accepted Answer

A)  inactive
B)  normal
C)  greatly reduced
D)  overactiveE) All of the above
F) None of the above

Question 7

What form must an mRNA assume in order to be targeted by miRNAs for degradation?

Accepted Answer

A)  a double-stranded form
B)  a nuclear form
C)  a single-stranded form
D)  a stem-loop formE) B) and C)
F) A) and C)

Question 8

Explain how combinatorial gene regulation allows eukaryotes to coordinate the expression of different genes very efficiently.

Accepted Answer

Eukaryotes have a large number of genes,...

Question 9

Each steroid hormone can bind to its own steroid hormone response unit (SHRU) but NOT to the SHRU associated with other steroid hormones.

Accepted Answer

A) True 
 B)False

Question 10

The DNA that encodes siRNA is NOT normally found in the nucleus.

Accepted Answer

A) True 
 B)False

Question 11

Match each term with its definition.
-repressor

Accepted Answer

A)  regulatory protein that activates the expression of an operon's genes
B)  interfering RNA molecules originally encoded by nuclear DNA
C)  process of controlling the expression of genes that takes place at the DNA level
D)  regulatory protein that prevents an operon's genes from being expressed
E)  inhibition of transcription via DNA methylationF) interfering RNA molecules associated with some viral life cyclesG) tumour comprising cells that invade and disrupt the surrounding tissuesH) increases expression of an operon's genesI) cluster of prokaryotic genes and their associated DNA regulatory sequencesJ) tumour comprising undifferentiated cells that stay together in a single massK) spread of malignant cells through the blood or lymphatic systemL) removes a nucleosome from DNA to expose a promoterM) D) and G)
N) B) and D)

Question 12

Identify each labelled part of this illustration of eukaryotic DNA. 
-activators

Accepted Answer

The answer of Identify each labelled part of this illustration...

Question 13

Which of the following best describes the general strategy of metabolic gene regulation in prokaryotes?

Accepted Answer

A)  Genes are always on for early steps in the pathway, but genes for later steps are generally off.
B)  Genes are turned on and off as conditions change.
C)  Genes are independently regulated.
D)  Genes are always on so the bacteria can respond rapidly to changing conditions.E) A) and B)
F) A) and C)

Question 14

Why do prokaryotic organisms tend to undergo rapid and reversible alterations in their genes?

Accepted Answer

A)  They are not as advanced.
B)  They are small.
C)  They are simple.
D)  They grow quickly.E) A) and B)
F) None of the above

Question 15

Which of the following best explains why E. coli shuts down the trp operon if tryptophan is available in the environment?

Accepted Answer

A)  It does not shut down the trp operon, it only lowers the level of trp operon activity.
B)  The trp operon encodes genes that export tryptophan from the cell; if tryptophan already occurs in the environment, further export is not necessary.
C)  Synthesizing an amino acid takes energy, so it is a waste of energy to make something that is already available.
D)  Environmental tryptophan is of higher quality than what the E. coli can make itself.E) None of the above
F) A) and D)

Question 16

Any gene could, theoretically, be specifically silenced by RNAi.

Accepted Answer

A) True 
 B)False

Question 17

To which portion of the DNA does a steroid hormone receptor bind?

Accepted Answer

A)  a response element
B)  an enhancer
C)  a gene promoter
D)  an operatorE) A) and B)
F) A) and C)

Question 18

Which types of proteins do proto-oncogenes tend to be?

Accepted Answer

A)  protein phosphorylases
B)  membrane-associated proteins
C)  extracellular receptors and protein kinases
D)  intracellular receptorsE) None of the above
F) A) and B)

Question 19

Which statement refers to genomic imprinting?

Accepted Answer

A)  An allele of a given gene is spliced during gametogenesis.
B)  An allele of a given gene is enhanced during gametogenesis.
C)  An allele of a given gene is activated during gametogenesis.
D)  An allele of a given gene is silenced during gametogenesis.E) A) and B)
F) A) and C)

Question 20

Match each term with its definition.
-miRNA

Accepted Answer

A)  regulatory protein that activates the expression of an operon's genes
B)  interfering RNA molecules originally encoded by nuclear DNA
C)  process of controlling the expression of genes that takes place at the DNA level
D)  regulatory protein that prevents an operon's genes from being expressed
E)  inhibition of transcription via DNA methylationF) interfering RNA molecules associated with some viral life cyclesG) tumour comprising cells that invade and disrupt the surrounding tissuesH) increases expression of an operon's genesI) cluster of prokaryotic genes and their associated DNA regulatory sequencesJ) tumour comprising undifferentiated cells that stay together in a single massK) spread of malignant cells through the blood or lymphatic systemL) removes a nucleosome from DNA to expose a promoterM) E) and I)
N) D) and G)

Exam 14: Control of Gene Expression

Each steroid hormone can bind to its own steroid hormone response unit (SHRU) but NOT to the SHRU associated with other steroid hormones.

Correct AnswerverifiedShow Answer

What happens to a DNA promoter sequence when it is methylated?

Correct AnswerverifiedShow Answer

The DNA that encodes siRNA is NOT normally found in the nucleus.

Correct AnswerverifiedShow Answer

Which of the following best describes the general strategy of metabolic gene regulation in prokaryotes?

Correct AnswerverifiedShow Answer

Which types of proteins do proto-oncogenes tend to be?

Correct AnswerverifiedShow Answer

To which portion of the DNA does a steroid hormone receptor bind?

Correct AnswerverifiedShow Answer

Match each term with its definition. -operon

Correct AnswerverifiedShow Answer

Match each term with its definition. -miRNA

Correct AnswerverifiedShow Answer

What form must an mRNA assume in order to be targeted by miRNAs for degradation?

Correct AnswerverifiedShow Answer

Genes in operons are transcribed in such a way as to share which of the following molecules?

Correct AnswerverifiedShow Answer

Identify each labelled part of this illustration of eukaryotic DNA. -activators

Correct AnswerverifiedShow Answer

Suppose that you observe a mutant E. coli in which CAP is always inactive. In the presence of lactose and low levels of glucose, what would you expect the gene expression from this mutant's lac operon to be?

Correct AnswerverifiedShow Answer

Which statement refers to genomic imprinting?

Correct AnswerverifiedShow Answer

Any gene could, theoretically, be specifically silenced by RNAi.

Correct AnswerverifiedShow Answer

Which of the following best explains why E. coli shuts down the trp operon if tryptophan is available in the environment?

Correct AnswerverifiedShow Answer

Match each term with its definition. -repressor

Correct AnswerverifiedShow Answer

Explain how combinatorial gene regulation allows eukaryotes to coordinate the expression of different genes very efficiently.

Correct AnswerverifiedEukaryotes have a large number of genes,...View AnswerShow Answer

Why do prokaryotic organisms tend to undergo rapid and reversible alterations in their genes?

Correct AnswerverifiedShow Answer

Eukaryotic genes consist of protein-coding sequences and adjacent regulatory sequences.

Correct AnswerverifiedShow Answer

What is one function of the 5? UTR (untranslated region) of mRNA?

Correct AnswerverifiedShow Answer

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Eukaryotes have a large number of genes,...
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